4. Biology and argumentation of fracture, cartilage and tendon repair.
Our team has long-term research interests in fracture repair biology and argumentation. We have successfully developed mouse and rat fracture repair model and identified the factors that affect the fracture repair outcome such as mechanical factors, inflammation, growth factors as well as genes and microRNAs. We have also tested novel methods for promoting fracture healing such as using stem cells, growth factors, Sclerostin antibody etc. We also developed animal models for cartilage and tendon repair; and we have recently reported novel involvement of non-coding long chain RNAs in tendon stem cell differentiation and cartilage repair. We have found that Smad7 plays an important role in bone development and osteoporosis. We will continue to explore the novel biological mechanisms and applications for musculoskeletal tissue repair and regeneration.
PPT: Bone fracture repair biology and animal models
PPT: Tendon repair studies |
Representative Publications:
1. miRNA-29b improves bone healing in mouse fracture model. Lee WYW Lee, Li N, Lin SE, Wang B, Lan HY, Li G. Molecular and Cellular Endocrinology, 2016; in press.
2. Lu YF, Li G, Chan KM, Zhang JF. Tendon differentiation and noncoding RNA: from bench to bedside. Experimental Cell Research, 2016; in press.
3. Guo J, Chan KM, Zhang JF, Li G. Tendon-derived stem cells undergo spontaneous tenogenic differentiation. Experimental Cell Research, 2016; 341:1-7.
4. Liu Y, Rui YF, Cheng TY, Huang S, Xu LL, Meng FB, Lee W, Ke HZ, Li G. Effects of sclerostin antibody on the healing of femoral fractures in ovariectomised rats. Calcified Tissue International, 2016; 98(3): 263-274.
5. Zhu M, Lin S, Feng Q, Sun Y, Li G, Bian L. Hydrogels functionalized with N-cadherin mimetic peptide enhance the osteogenesis of hMSCs by emulating the oteogenic niche. Biomaterials, 2016; 77:44-52.
6. Huang S, Xu LL, Sun YX, Zhang YF, Li G. The fate of systemically administrated allogeneic mesenchymal stem cells (MSCs) in mouse femoral fracture healing. Stem Cell Research and Therapy, 2015, 6: 206.
7. Wang KX, Xu LL, Rui YF, Huang S, Lin SE, Xiong JH, Li YH, Lee WYW, Li G. The effects of secretion factors from umbilical cord derived mesenchymal stem cells on osteogenic differentiation of mesenchymal stem cells. PLoS One, 2015; 10(3): e0120593.
8. Li N, Lee YW, Lin SE, Ni M, Zhang T, Huang XR, Lan HY, Li G. Partial loss of Smad7 function impairs osteogenesis and enhances osteoclastogenesis in mice. Bone, 2014; 67: 46-55.
9. Ni M, Rui YF, Tan Q, Liu Y, Xu LL, Chan KM, Wang Y, Li G. Engineered scaffold-free tendon tissue produced by tendon-derived stem cells. Biomaterials, 2013; 34: 2024-2037.
10. Zhang G, Guo B, Wu H, Tang T, Zhang B, Zheng L, He Y, Yang Z, Pan X, Chow H, To K, Li Y, Li D, Wang X, Wang Y, Lee K, Hou Z, Dong N, Li G, Leung K, Hung L, He F, Zhang L, Qin L. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine, 2012; 18(2): 307-14 |